I would actually use it directly most of the time, not that your points aren't valid. I guess a middle ground can be a TUI. If done well/enough Vim-like it would be even better.
As for the scripting languages, while I do plan to utilize them at a further point in time, I have been a PHP developer most of the time and any libusb wrappers there are, don't work with the latest version or fail during compilation. I am currently learning C, but don't know it well enough to use libusb directly. Perl and Python are a bit further down on my list for languages to learn.
Also, not that there aren't any other viable (maybe even better) alternatives than CLI for libusb. My reason for requesting a clip USB application in particular is mostly because I just want to do it via the terminal I requested cli as opposed to TUI as it is more versatile and depending on how the TUI is done, it may not be to everyone's taste. Not that I'd mind having either one or both